sry-box-6 protein; transcription factor SOX-6 (sox6)

Function

• transcriptional activator
• binds specifically to the DNA sequence 5'-AACAAT-3'
• plays a key role in several developmental processes, including neurogenesis & skeleton formation
• interacts with DAZAP2 (putative)
• sumoylation inhibits the transcriptional activity

Structure

contains 1 HMG box DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in a wide variety of tissues
• highest expression in skeletal muscle

More general terms

• sox protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5555
• UniProt: http://www.uniprot.org/uniprot/P35712.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55553