ATP-dependent DNA helicase HEL308; mus308-like helicase (HEL308, HELQ)

Function

• DNA-dependent ATPase & 5' to 3' DNA helicase
• ATPase activity is stimulated by single-stranded DNA
• presence of ATP & Mg cofactor are required for helicase activity allowing to unwind duplex oligonucleotides up to 60-70-mer
• helicase activity is stimulated by replication protein RPA that binds to unwound regions & inhibits re-annealing

Structure

• hexamer
• belongs to the helicase family. SKI2 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Alternative splicing

named isoforms=5

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• OMIM: https://mirror.omim.org/entry/606769
• UniProt: http://www.uniprot.org/uniprot/Q8TDG4.html