ATP-dependent RNA helicase DHX58; ATP-dependent helicase LGP2; protein D11Lgp2 homolog; RIG-I-like receptor LGP2; RLR (DHX58, D11LGP2E, LGP2)

Function

• role in innate immune defense against viruses
• upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction & expression of antiviral cytokines such as IFN-beta & RANTES (CCL5)
• the RNA helicase domain may recognize & structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower
• homodimer; binds dsRNA as a homodimer
• interacts with DDX58 & probably blocks its homomultimerization

ATP + H2O = ADP + phosphate

Cofactor: Zn+2

Structure

• belongs to the helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

cytoplasm

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79132
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79132
• OMIM: https://mirror.omim.org/entry/608588
• UniProt: http://www.uniprot.org/uniprot/Q96C10.html