F-box only protein 18; F-box DNA helicase 1 (FBXO18, FBH1, FBX18)

Function

• DNA-dependent ATPase.
• unwinds double-stranded DNA in a 3' to 5' direction
• probably recognizes & binds to some phosphorylated proteins & promotes their ubiquitination & degradation
• part of a SCF complex
• interacts with SKP1

Structure

• belongs to the helicase family, UvrD subfamily
• contains 1 F-box domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

More general terms

• F-box only protein
• helicase (DNA unwinding protein, DNA untwisting protein)

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84893
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84893
• OMIM: https://mirror.omim.org/entry/607222
• UniProt: http://www.uniprot.org/uniprot/Q8NFZ0.html