F-box only protein 6; F-box/G-domain protein 2; F-box protein that recognizes sugar chains 2 (FBXO6 FBG2 FBS2 FBX6)

Function

• substrate-recognition component of some SCF complexes
• involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing & binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol & promoting their ubiquitination & subsequent degradation
• able to recognize & bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides
• also recognizes sulfated glycans
• also involved in DNA damage response by specifically recognizing activated CHK1 (phosphorylated on Ser-345), promoting its ubiquitination & degradation; ubiquitination of CHK1 is required to insure that activated CHK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication
• interacts with CHK1 & CUL1

Structure

• contains 1 F-box domain
• contains 1 FBA (F-box associated) domain

Compartment

cytoplasm

More general terms

• F-box only protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26270
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26270
• OMIM: https://mirror.omim.org/entry/605647
• UniProt: http://www.uniprot.org/uniprot/Q9NRD1.html