somatostatin receptor 4; SS4R; brain-specific somatostatin receptor (SSTR4)

Function

• receptor for somatostatin-14
• activity mediated by G proteins which inhibit adenylyl cyclase
• functionally coupled to
  • inhibition of adenylate cyclase
  • activation of arachidonate release & mitogen-activated protein (MAP) kinase cascade
• mediates antiproliferative action of somatostatin in tumor cells

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• specifically expressed in fetal & adult brain, lung tissue, stomach
• lesser expression in kidney, pituitary & adrenals

More general terms

• somatostatin receptor
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/182454
• UniProt: http://www.uniprot.org/uniprot/P31391.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6754