histamine H2 receptor; H2R; gastric receptor I (HRH2)

Function

• H2 subclass of histamine receptors mediates gastric acid secretion
• also appears to regulate gastrointestinal motility & intestinal secretion
• possible role in regulating cell growth & differentiation
• activity is mediated by G proteins which activate adenylyl cyclase (Gs proteins) &, through a separate G protein-dependent mechanism, the phosphoinositide/ protein kinase C (PKC) signaling pathway (putative)

Structure

• belongs to the G-protein coupled receptor 1 family
• membrane pocket formed by 7 transmembrane regions forms ligand binding site & provides for interaction of receptor with G protein

Compartment

cell membrane

Pharmacology

• histamine-H2-receptor antagonists are used in treatment of gastirc acid disorders, i.e. dyspepsia, peptic ulcer disease, gastritis, GERD

More general terms

• histamine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3274
• OMIM: https://mirror.omim.org/entry/142703
• UniProt: http://www.uniprot.org/uniprot/P25021.html