iroquois-class homeodomain protein IRX-5; homeodomain protein IRX-2A; homeodomain protein IRXB2; iroquois homeobox protein 5 (IRX5, IRX2A, IRXB2)

Function

• establishes the cardiac repolarization gradient by its repressive actions on the KCND2 K+-channel gene
• required for retinal cone bipolar cell differentiation
• may regulate contrast adaptation in the retina & control specific aspects of visual function in circuits of the mammalian retina

Structure

• belongs to the TALE/IRO homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Pathology

• could be involved in the regulation of both the cell cycle & apoptosis in prostate cancer cells
• down-regulated by 1,25-dihydroxyvitamin D3 in prostate cancer samples from patients assigned to receive weekly high-dose 1,25-dihydroxyvitamin D3 before radical prostatectomy
• also down- regulated by 1,25-dihydroxyvitamin D3 in the human androgen-sensitive prostate cancer cell line LNCaP & in the estrogen-sensitive breast cancer cell line MCF-7

More general terms

• Iroquois-class homeodomain protein IRX

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10265
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10265
• OMIM: https://mirror.omim.org/entry/606195
• UniProt: http://www.uniprot.org/uniprot/P78411.html