DnaJ homolog subfamily C member 3; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58 (DNAJC3, P58IPK, PRKRI)

Function

• role in unfolded protein response during cellular stress
• stimulates ATPase activity of HSPA8
• may inhibit
  • EIF2AK2 autophosphorylation & the ability of EIF2AK2 to phosphorylate EIF2A
  • EIF2AK3

Structure

• the J domain mediates interaction with HSPA8
• binding to misfolded proteins is mediated by a hydrophobic patch forming a large groove within the first two TPR repeats
• contains 1 J domain
• contains 9 TPR repeats

Compartment

• cytoplasm
• associated with the endoplasmic reticulum

Expression

• widely expressed
• highly expressed in the pancreas & testis
• up-regulated during an endoplasmic reticulum stress via ATF6
• down-regulated by DNAJB1 & PRKRIR/P52RIPK
• up-regulated in response to infection by influenza virus through the dissociation of DNAJB1

More general terms

• DNAJ homolog subfamily C

Database

• OMIM: https://mirror.omim.org/entry/601184
• UniProt: http://www.uniprot.org/uniprot/Q13217.html