52 kD repressor of the inhibitor of the protein kinase; p58IPK-interacting protein; 58 kD interferon-induced protein kinase-interacting protein; P52rIPK; Death-associated protein 4; THAP domain-containing protein 0 (PRKRIR, DAP4, P52RIPK, THAP0)

Function

• upstream regulator of interferon-induced s serine/threonine protein kinase R (PKR)
• may block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity & suppression of cell growth
• interacts with P58IPK, probably sequestring it

Structure

contains 1 THAP-type Zn+2 finger

Alternative splicing

named isoforms=2

More general terms

• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5612
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5612
• OMIM: https://mirror.omim.org/entry/607374
• UniProt: http://www.uniprot.org/uniprot/O43422.html