indolethylamine N-methyltransferase; indolamine N-methyltransferase; aromatic alkylamine N-methyltransferase; amine N-methyltransferase; arylamine N-methyltransferase (INMT)

Function

• catalyzes N-methylation of tryptamine & structurally related compounds (putative)

S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine

Kinetic parameters:

• KM=2.9 mM for tryptamine

Structure

• monomer (putative)
• belongs to the NNMT/PNMT/TEMT family

Compartment

cytoplasm (putative)

Expression

• widely expressed
• expresse in thyroid, adrenal gland, adult & fetal lung > heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node & trachea > adult & fetal kidney & liver, in adult spleen, thymus, ovary, colon & bone marrow
• not expressed in peripheral blood leukocytes, brain

More general terms

• N-methyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11185
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11185
• OMIM: https://mirror.omim.org/entry/604854
• UniProt: http://www.uniprot.org/uniprot/O95050.html