phenylethanolamine N-methyltransferase (PNMT, noradrenaline N-methyltransferase)

Function

• converts noradrenaline to adrenaline
• catecholamine biosynthesis; last step

S-adenosyl-L-methionine + phenylethanolamine
                <-->
S-adenosyl-L-homocysteine + N-methylphenylethanolamine

Kinetic parameters:

• KM=99 uM for phenylethanolamine
• KM=3.4 uM for S-adenosyl-L-methionine

Structure

belongs to the NNMT/PNMT/TEMT family

More general terms

• N-methyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/P11086.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5409
• OMIM: https://mirror.omim.org/entry/171190
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5409