nicotinamide N-methyltransferase (NNMT)

Function

• catalyzes N-methylation of nicotinamide & other pyridines to form pyridinium ions
• role in biotransformation of many drugs & xenobiotics

S-adenosyl-L-methionine + nicotinamide
          <-->
S-adenosyl-L-homocysteine + 1-methylnicotinamide

Structure

• monomer
• belongs to the NNMT/PNMT/TEMT family

Compartment

cytoplasm

Expression

• predominantly expressed in the liver
• lower expression in kidney, lung, skeletal muscle, placenta & heart
• not detected in the brain or pancreas

More general terms

• methyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/P40261.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4837
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4837
• OMIM: https://mirror.omim.org/entry/600008