N-acetyltransferase 10 (NAT10, ALP, KIAA1709)

Function

• histone acetyltransferase in vitro
  • can acetylate both histones & microtubules
  • histone acetylation may regulate transcription & mitotic chromosome de-condensation
• activates telomerase activity by stimulating transcription of TERT, & may also regulate telomerase function by affecting balance of telomerase subunit assembly, disassembly, & localization
• acetylates alpha-tubulin, which may affect microtubule stability & cell division
• interacts with SUN1 (via N-terminus)
• possible role in DNA damage & induction of cellular resistance to genotoxic agents

Structure

• belongs to the UPF0202 family
• contains 1 N-acetyltransferase domain

Compartment

• nucleus, nucleolus
• nucleolar in interphase
• redistributes to the perichromosomal layer & to the midbody during telophase

Expression

• transcriptionally activated by genotoxic agents

More general terms

• acetyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55226
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55226
• OMIM: https://mirror.omim.org/entry/609221
• UniProt: http://www.uniprot.org/uniprot/Q9H0A0.html