inosine-5'-monophosphate dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPDH 2; IMPDH-II (IMPDH2, IMPD2)
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Function
- rate limiting enzyme in the de novo synthesis of guanine nucleotides, thus role in regulation of cell growth
- may also have a role in the development of malignancy & the growth progression of some tumors
- purine metabolism; XMP biosynthesis via de novo pathway
- XMP from IMP: step 1/1
inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH
Structure
Expression
- IMP type 1 predominate in normal leukocytes
- IMP type 2 predominates over type 1 in tumors