GMP reductase 1; guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1 (GMPR, GMPR1)

Function

• <A15850>catalyzes</A15850> irreversible <A17822>NADPH</A17822>-dependent deamination of GMP to IMP
• functions in the conversion of nucleobase, nucleoside & nucleotide derivatives of G to A nucleotides, & in maintaining the intracellular balance of A & G nucleotides

inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH

Structure

• homotetramer
• belongs to the IMPDH/GMPR family

Polymorphism

• at least two different alleles are known

Notes

• the N-terminus was initially thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD)

More general terms

• amine oxidoreductase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2766
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2766
• OMIM: https://mirror.omim.org/entry/139265
• UniProt: http://www.uniprot.org/uniprot/P36959.html