DNA repair & recombination protein RAD54B; RAD54 homolog B (RAD54B)

Function

• role in DNA repair & mitotic recombination
• may play an active role in recombination processes in concert with other members of the RAD52 epistasis group
• interacts with RAD51 through the NH2-terminal domain
  • interaction is constitutive & not induced by ionizing radiation
  • interaction may be indirect

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

nucleus (probable)

Expression

• abundantly expressed in testis & spleen
• lesser expression in thymus, prostate, ovary & colon

More general terms

• DEAD box ATP-dependent helicase
• phosphoprotein

Additional terms

• DNA repair

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25788
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25788
• OMIM: https://mirror.omim.org/entry/604289
• UniProt: http://www.uniprot.org/uniprot/Q9Y620.html