granzyme-A; granzyme-1; fragmentin-1; Hanukkah factor; cytotoxic T lymphocyte-associated serine esterase-3; CTLA-3; cytotoxic T-lymphocyte proteinase 1; CTL tryptase (GZMA, CTLA3, HFSP)

Function

• necessary for target cell lysis in cell-mediated immune responses
• cleaves after Lys or Arg
• may be involved in apoptosis
• trypsin-like specificity
• hydrolysis of proteins, including fibronectin, type IV collagen & nucleolin
• preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates

Structure

• homodimer, disulfide-linked
• belongs to the peptidase S1 family, Granzyme subfamily
• contains 1 peptidase S1 domain

Compartment

secreted, cytoplasmic granule

More general terms

• granzyme, cytotoxic T-cell protease; CTL tryptase; fragmentin

Database

• UniProt: http://www.uniprot.org/uniprot/P12544.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3001
• OMIM: https://mirror.omim.org/entry/140050
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3001