fucosyltransferase-5; alpha (1,3) fucosyltransferase (FUT5)

Function

• may catalyze alpha-1,3 glycosidic linkages involved in expression of VIM-2, Lewis X/SSEA-1 & sialyl Lewis X antigens
• protein modification; protein glycosylation

GDP-beta-L-fucose +  beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R
          <-->
GDP +
beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))- N-acetyl-beta-D-glucosaminyl-R

Structure

belongs to the glycosyltransferase 10 family

Compartment

• Golgi, Golgi membrane
• membrane-bound form in trans cisternae of Golgi

Expression

• liver, colon & testis
• trace amounts in T-cells & brain

More general terms

• fucosyltransferase

Additional terms

• alpha-(1,3)-fucosyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2527
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2527
• OMIM: https://mirror.omim.org/entry/136835
• UniProt: http://www.uniprot.org/uniprot/Q11128.html