8-oxoguanine DNA glycosylase; N-glycosylase/DNA lyase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase (OGG1, MMH, MUTM, OGH1, FAPY)

Function

• DNA repair enzyme that incises DNA at 8-oxoG residues
• excises 7,8-dihydro-8-oxoguanine & 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA
• as a beta-lyase activity that nicks DNA 3' to the lesion
• the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar & a product with a terminal 5'-phosphate

Structure

belongs to the type-1 OGG1 family

Compartment

• isoform 1A: nucleus
• isoform 2A: mitochondrion

Alternative splicing

named isoforms=8

Expression

ubiquitous

Pathology

• defects in OGG1 are associated with tumor formation
• defects in OGG1 are a cause of renal cell carcinoma

More general terms

• DNA glycosylase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4968
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4968
• OMIM: https://mirror.omim.org/entry/144700
• OMIM: https://mirror.omim.org/entry/601982
• UniProt: http://www.uniprot.org/uniprot/O15527.html