Large subunit GTPase 1 homolog (hLsg1, LSG1)

Function

• GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit
• probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm

Structure

• in contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern
• belongs to the MMR1/HSR1 GTP-binding protein family LSG1 subfamily

Compartment

• cytoplasm, nucleus, endoplasmic reticulum
• shuttles between the Cajal bodies in the nucleus & the endoplasmic reticulum

More general terms

• guanosine triphosphatase (GTPase)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H089.html