cytosolic 5'-nucleotidase 1A (cN1A, NT5C1A)

Function

• dephosphorylates the 5' & 2'(3')-phosphates of deoxyribonucleotides
• broad substrate specificity
• regulation of adenosine levels in heart during ischemia & hypoxia
• activated by ADP

Structure

belongs to the 5'-nucleotidase type 3 family

Compartment

cytoplasm

Expression

• expressed in skeletal muscle > heart, brain, kidney, pancreas

Pathology

• NT5C1A autoantibody in patients with inclusion body myositis

More general terms

• 5'nucleotidase (5'-ribonucleotide phosphohydrolase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84618
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84618
• OMIM: https://mirror.omim.org/entry/610525
• UniProt: http://www.uniprot.org/uniprot/Q9BXI3.html