myosin-18a; molecule associated with JAK3 N-terminus; MAJN; myosin containing a PDZ domain (MYO18A, KIAA0216 MYSPDZ)

Function

• may be involved in the maintenance of the stromal cell architectures required for cell to cell contact (putative)
• interacts with JAK3 & actin

Structure

• homodimer
• contains 1 IQ domain
• contains 1 myosin head-like domain
• contains 1 PDZ domain (DHR domain)
  • isoform 2 lacks the PDZ domain

Compartment

• isoform 1:
  • endoplasmic reticulum-Golgi intermediate compartment (putative)
  • cytoplasm, cytoskeleton
  • colocalizes with actin
• isoform 2: diffusely localized in the cytoplasm

Alternative splicing

named isoforms=5

Notes

• TIAF1 protein is coded in the 3'-UTR region of MYO18A gene

More general terms

• unconventional myosin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=399687
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:399687
• OMIM: https://mirror.omim.org/entry/609517
• OMIM: https://mirror.omim.org/entry/610067
• UniProt: http://www.uniprot.org/uniprot/Q92614.html