myosin-5b (MYO5B, KIAA1119)

Function

• may be involved in vesicular trafficking via its association with the CART complex
• required in a complex with RAB11A & RAB11FIP2 for transport of NPC1L1 to the plasma membrane
• together with RAB11A participates in CFTR trafficking to the plasma membrane & transferrin recycling in nonpolarized cells
• together with RAB11A & RAB8A participates in epithelial cell polarization
• together with RAB25 regulates transcytosis (putative)
• interacts with RAB11FIP2, RAB11A, & RAB8A
• found in a complex with CFTR & RAB11A
• interacts with NPC1L1

Structure

• contains 1 dilute domain
• contains 6 IQ domains
• contains 1 myosin head-like domain

Pathology

• defects in MYO5B are a cause of hereditary diarrhea type 2

More general terms

• unconventional myosin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4645
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4645
• OMIM: https://mirror.omim.org/entry/251850
• OMIM: https://mirror.omim.org/entry/606540
• UniProt: http://www.uniprot.org/uniprot/Q9ULV0.html