chromosomal translocation t(8;21)(q22;q22) (AML/ETO)

Introduction

Found in acute myeloid leukemias particularly AML-M2, 18-40% of cases depending on reference []2]. AML1-ETO knock-in mice (heterozygotes) died in mid-gestation from CNS hemorrhage & showed severe block of liver hematopoiesis, suggesting AML1-ETO fusion protein blocks normal AML1 protein or core binding factor alpha-2.

More general terms

• chromosomal translocation