PTB domain-containing engulfment adapter protein 1 (GULP, PTB domain adapter protein CED-6, cell death protein 6 homolog, GULP1, CED6, GULP)

Function

• may function as an adapter protein
• required for efficient phagocytosis of apoptotic cells
• modulates cellular glycosphingolipid & cholesterol transport
• may play a role in the internalization & endosomal trafficking of various LRP1 ligands, including PSAP
• increases cellular levels of GTP-bound ARF6
• interacts with clathrin
• interacts with GDP-bound ARF6, but not with GTP-bound ARF6
• part of a complex composed of GULP1, CENTB1 & ARF6
• interacts with CENTB1, LRP1 & MEGF10

Structure

• homodimer
• belongs to the ced-6 family
• contains 1 PID domain

Compartment

• cytoplasm
• may associate with cytoplasmic side of the plasma membrane & early endosomes

Alternative splicing

named isoforms=2

Expression

• widely expressed
• detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta & ovary

More general terms

• uncharacterized protein

Database

• OMIM: https://mirror.omim.org/entry/608165
• UniProt: http://www.uniprot.org/uniprot/Q9UBP9.html