plastin-3; T-plastin (PLS3)

Function

• actin-bundling protein found in intestinal microvilli, hair cell stereocilia, & fibroblast filopodia
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• monomer
• contains 2 actin-binding domains
• contains 4 CH (calponin-homology) domains
• contains 2 EF-hand domains

Compartment

cytoplasm

Expression

• expressed in a variety of organs, including muscle, brain, uterus & esophagus

More general terms

• plastin or fimbrin

Database

• UniProt: http://www.uniprot.org/uniprot/P13797.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5358
• OMIM: https://mirror.omim.org/entry/300131