systemic inflammatory response syndrome (SIRS)
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Introduction
Systemic inflammatory response to a variety of severe clinical insults in the absence of infection. Clinically SIRS resembles sepsis (without documented infection).
Clinical criteria: (same as for sepsis minus documented infection)
- temp > 38 C or < 36 C
- heart rate > 90/min
- respiratory rate > 20/min or paCO2 < 32 mm Hg
- WBC > 12,000 cells/mm3 or < 4000 cells/mm3 or > 10% bands
Etiology
- pancreatitis
- trauma
- envenomation
- disseminated intravascular coagulation (DIC)
- tumor necrosis syndrome
- myonecrosis
- burns
Clinical manifestations
see sepsis
Laboratory
see sepsis
Radiology
see sepsis
Management
see sepsis
Comparative biology
- topoisomerase-1 inhibitor protected mice from death in experimental models of lethal inflammation[2]
More general terms
More specific terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
- ↑ 2.0 2.1 Rialdi A et al. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science 2016 May 27; 352:aad7993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27127234