topoisomerase-1 inhibitor
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Mechanism of action
- antineoplastic agents that inhibit topoisomerase-1
- topoisomerase 1 acts as a positive regulator of RNA polymerase II transcriptional activity at pathogen- induced genes[1]
- suppresses host response against viral & bacterial antigens
Comparative biology
- topoisomerase-1 inhibitor protected mice from death in experimental models of lethal inflammation[1]
More general terms
More specific terms
- irinotecan; camptothecin (Camptosar, Topotecin, Onivyde, CPT-11)
- topotecan (Hycamtin, SKF-104864A, Topo, TPT)
Additional terms
References
- ↑ 1.0 1.1 1.2 Rialdi A et al. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science 2016 May 27; 352:aad7993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27127234