protein kinase C-beta 1 (PKC-IIa, PRKCB1)

Function

• Ca+2-activated, phospholipid-dependent, Ser- & Thr- specific enzyme
• component of the NF-kappa-B signaling axis responsible for survival & activation of B-cells after BCR cross-linking
• phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate; subsequent autophosphorylation of Thr-642 maintains catalytic competence, & autophosphorylation on Ser-661 appears to release the kinase into the cytosol
• similarly, isoform beta-II is autophosphorylated on Thr-640 & Ser-659, subsequent to phosphorylation on Thr-500
• autophosphorylated on other sites i.e in the N-terminal & hinge regions have no effect on PKC activity
• interacts with PDK1, PRKCBP1

Cofactor: binds 3 Ca+2 per subunit; binds via C2 domain

Compartment

cytoplasm, peripheral membrane

More general terms

• protein kinase C-beta (PKC-II, PRKCB1, PKCB, PRKCB)

Database

• UniProt: http://www.uniprot.org/uniprot/P05771.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5579
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5579
• OMIM: https://mirror.omim.org/entry/176970