drug-related vasculitis
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Etiology
- antimicrobial agents
- vaccines
- antithyroid agents:
- propylthiouracil (80-90%)
- less frequently methimazole, carbimazole, benzylthiouracil
- anticonvulsants: phenytoin
- antiarrhythmic agents & other cardiovascular drugs
- diuretics, hydralzine
- anticoagulants
- antineoplastic agents
- diuretics: thiazides
- hematopoietic growth factors
- NSAIDs
- leukotriene inhibitors
- psychotropic drugs
- sympathomimetics
- allopurinol
- TNF-alpha inhibitors
- interferon alfa
- levamisole (associated with cocaine)
- gold*
* not listed in[2]
Clinical manifestations
- predominantly cutaneous manifestations
- palpable purpura most common form
- generalized
- limited to lower extremities & other dependent areas
- urticaria, ulceration & hemorrhagic blisters less common
- palpable purpura most common form
- systemic manifestations may occur
Laboratory
- mild leukocytosis with or without eosinophilia
- elevated erythrocyte sedimentation rate (ESR)
More general terms
References
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1919
- ↑ Jump up to: 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 16, 18 American College of Physicians, Philadelphia 2012, 2018.