pulmonary infiltrates with eosinophilia (PIE) syndrome

Introduction

A group of heterogenous disorders characterized by the presence of abnormalities on chest X-ray & eosinophilia.

Etiology

• asthma
• pulmonary eosinophilia
• allergic bronchopulmonary aspergillosis
• eosinophilic pneumonia
  • acute eosinophilic pneumonia
  • chronic eosinophilic pneumonia
• Churg-Strauss disease
• parasitic infections
  • Loffler syndrome
• pharmaceutical agents
• neoplasms associated with eosinophilia:
  • eosinophilic leukemia
  • adenocarcinoma of the lung
  • lymphoma
• tropical eosinophilia
• hypereosinophilic syndrome
• bronchocentric granulomatosis

Epidemiology

• travel to developing country

Clinical manifestations

• low grade fever
• dry cough
• wheezing

Laboratory

• stool for ova & parasites

Radiology

• patchy bilateral pulmonary infiltrates

Management

• long-term systemic glucocorticoids
• case of symptoms & radiology findings clearing with 5 days of prednisone

More general terms

• pulmonary infiltrate
• pulmonary esosinophilia
• syndrome

More specific terms

• acute eosinophilic leukemia
• allergic angiitis & granulomatosis of Churg-Strauss; eosinophilic granulomatosis with polyangiitis (EGPA)
• allergic bronchopulmonary aspergillosis; allergic bronchopulmonary mycosis (ABPA)
• bronchocentric granulomatosis
• drugs causing eosinophilia
• eosinophilic asthma
• eosinophilic pneumonia; Andrews syndrome; pulmonary eosinophilia
• hypereosinophilic syndrome
• Loffler's syndrome (simple pulmonary eosinophilia)
• tropical eosinophilia

Additional terms

• eosinophilia
• parasites frequently associated with eosinophilia