acute eosinophilic leukemia

Epidemiology

rare

Genetics

• t(8;9)(p22;p24) involving JAK2 with PCM1 are found in both chronic & acute forms of eosinophilic, lymphoblastic & myeloid leukemia
  • translocation links the protein kinase domain of JAK2 to PCM1
• t(5;12)(q31;p13) involving ETV6 with ACSL6

Laboratory

• complete blood count (CBC): marked eosinophilia
• peripheral smear: dysplastic eosinophils
• bone marrow biopsy: increased blasts

More general terms

• eosinophilic leukemia
• acute myeloid leukemia (AML)