C-X-C motif chemokine 10; 10 kD interferon gamma-induced protein; gamma-IP10; IP-10; small-inducible cytokine B10; contains: CXCL10(1-73) (CXCL10, INP10, SCYB10)

Function

• chemotactic for monocytes & T-lymphocytes
• binds to CXCR3
• CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes
• may be a mediator of the IFN-gamma response

Structure

• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

Expression

• induced by IFN-gamma
  • a diverse population of cell types rapidly increases transcription of mRNA encoding this protein

More general terms

• CXC chemokine; alpha chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3627
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3627
• OMIM: https://mirror.omim.org/entry/147310
• UniProt: http://www.uniprot.org/uniprot/P02778.html