10 kD heat shock protein, mitochondrial; Hsp10; 10 kD chaperonin; CPN10; early-pregnancy factor; EPF (HSPE1)

Function

• essential for mitochondrial protein biogenesis, together with CPN60
• binds to CPN60 in the presence of Mg-ATP & suppresses ATPase activity of CPN60
• chaperonin-10 complexes with chaperonin-60 & with hsp 70 in the TCP1 ring complex
• inhibits Toll-like receptors

Structure

• homohexamer
• belongs to the groES chaperonin family

Compartment

mitochondrial matrix

Expression

induced by stress

Comparative biology

• homologous to groES (in prokaryotes)

More general terms

• chaperonin; chaperone
• heat shock protein
• phosphoprotein

More specific terms

• recombinant chaperonin 10

Component of

• TCP1 ring complex (T-complex protein 1, chaperonin containing T-complex polypeptide 1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3336
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3336
• OMIM: https://mirror.omim.org/entry/600141
• UniProt: http://www.uniprot.org/uniprot/P61604.html