scyllo-inositol; cocositol; quercinitol; 1,3,5/2,4,6-hexahydroxycyclohexane (AZD-103)
(Redirected from 1,3,5/2,4,6-hexahydroxycyclohexane)
Jump to navigation
Jump to search
Introduction
one of the 8 naturally occuring stereoisomers of inositol
Epidemiology
- found most abundantly in the coconut palm
Dosage
Pharmacokinetics
- penetrates blood brain barrier
- administration leads to increases in CSF concentration
Adverse effects
Mechanism of action
- can block the development of beta-amyloid senile plaques in brains of transgenic mice
Clinical trials
More general terms
References
- ↑ PubChem: 892
- ↑ Wikipedia: scyllo-Inositol http://en.wikipedia.org/wiki/Scyllo-Inositol
- ↑ McLaurin J et al Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med. 2006 Jul;12(7):801-8. Epub 2006 Jun 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16767098
- ↑ 4.0 4.1 4.2 4.3 Salloway S et al A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology. 2011 Sep 27;77(13):1253-62. Epub 2011 Sep 14. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21917766 <Internet> http://www.neurology.org/content/77/13/1253.abstract
- ↑ Fenili D et al Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology. J Mol Med (Berl). 2007 Jun;85(6):603-11. Epub 2007 Feb 6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17279347