ziftomenib (Komzifti)

Indications

• adults & chilfren with relapsed/refractory NPM1-mutated AML

Adverse effects

• differentiation syndrome
• QTc interval prolongation & Torsades de Pointes
• embryo-fetal toxicity

Mechanism of action

• menin inhibitor

More general terms

• small inhibitory antineoplastic agent (ib drug)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=138497449
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=130440656