differentiation syndrome

Etiology

• enasidenib (Idhifa)

Clinical manifestations

• fever
• dyspnea, acute respiratory distress
• pulmonary infiltrates
• pleural effusion
• pericardial effusion
• peripheral edema
• liver failure
• acute renal failure
• multi-organ dysfunction

Complications

• can be fatal if not treated

Management

• glucocorticoids with close monitoring until symptoms abare

More general terms

• drug adverse effect(s)
• syndrome