SAFE study

Introduction

Design:

• double blind trial
• 7000 surgical or medical intensive care unit patients
• 64% with mechanical ventilation
• 44% with organ failure (1 or more organs)

Fluid resuscitation with normal saline or 4% albumin

Results:

• all cause mortality same in both groups at 21 days
• a trend toward improved outcome with 4% albumin observed in septic patients
• a trend toward improved outcome with normal saline observed in head trauma patients

More general terms

• clinical trial