cow's milk hypersensitivity (CMH); cow's milk allergy

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Introduction

Also see food allergy

Epidemiology

  • 2-3% of infants
  • most children outgrow it
    • only 1/2 of children with milk allergy outgrow it by 5 years of age[3][6]
  • 75% can tolerate milk in a baked product[2]

Clinical manifestations

Laboratory

  • milk-specific IgE

Diagnostic procedures

skin testing

Complications

Differential diagnosis

Management

  • supervised baked milk challenges for milk-allergic children[2]
  • ability to tolerate baked milk predicts outgrowth of milk allergy[2]
  • regular consumption of milk in baked goods speeds resolution of milk allergy[6]
  • comment: its seems a trial of soy milk might be in order

More general terms

Additional terms

References

  1. Journal Watch 24(8):67, 2004
    Vanto T et al Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity. J Pediatr 144:218, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14760265
  2. 2.0 2.1 2.2 2.3 Kim JS et al. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol 2011 May 23; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21601913 <Internet> http://www.sciencedirect.com/science/article/pii/S0091674911006749
  3. 3.0 3.1 3.2 Wood RA et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 2013 Mar; 131:805. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23273958 <Internet> http://www.jacionline.org/article/S0091-6749(12)01859-3/abstract
    Spergel JM. Natural history of cow's milk allergy. J Allergy Clin Immunol 2013 Mar; 131:813. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23452903 <Internet> http://www.jacionline.org/article/S0091-6749(13)00187-5/abstract
  4. De Greef E, Hauser B, Devreker T et al Diagnosis and management of cow's milk protein allergy in infants. World J Pediatr. 2012 Feb;8(1):19-24. Epub 2012 Jan 27. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22282379
  5. Vandenplas Y, De Greef E, Devreker T. Treatment of Cow's Milk Protein Allergy. Pediatr Gastroenterol Hepatol Nutr. 2014 Mar;17(1):1-5. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24749081
  6. 6.0 6.1 6.2 Efron A, Zeldin Y, Gotesdyner L et al. A structured gradual exposure protocol to baked and heated milk in the treatment of milk allergy. J Pediatr 2018 Sep 27 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30270168