SU.VLMAX study

Introduction

Design:

• 13,017 adults;
  • 5141 men, mean age 51
  • 7876 women, mean age 47
• 7.5 years of follow-up

Treatment:

• antioxidant combination of: ascorbate 120 mg vitamin E 30IU beta-carotene 6 mg selenium 100 ug Zn+2 20 mg
• placebo

Results:

• overall, no reduction in risk of cancer, cardiovascular disease, or mortality
• in men, significant reductions in cancer (RR 0.69) & mortality (RR 0.63)
• in men in placebo group, cancer risk negatively correlated with baseline beta-carotene levels (RR for highest quintile relative to lowest quintile = 0.55)

More general terms

• clinical trial

Additional terms

• antioxidant