Modification of diet in Renal Disease (MDRD) Study

Introduction

Study characteristics:

• 840 adults with chronic renal disease
• 95% without diabetes mellitus
• serum creatinine > 1.4 mg/dL (men) 1.2 mg/dL women

Treatment:

• patients randomized to target blood pressures of < 125/75 mm Hg vs < 140/90 mm Hg (control)
• target blood pressure slightly higher for elderly (> 60)
• to achieve goals. physicians encouraged to use:
  • non pharmacologic therapy
  • ACE inhibitors, diuretics, Ca+2 channel blockers

Median follow-up of 5.9 years

Results:

• lower target blood pressure group less likely to experience
  • renal failure (62% vs 70%)
  • combined endpoint of death or renal failure (72% vs 76%)
• no effect of target blood pressure on proteinuria

Notes

• renal function (GFR) estimated by MDRD study equation

More general terms

• clinical trial

Additional terms

• Modification of diet in Renal Disease (MDRD) Study