atypical vs conventional antipsychotics in the elderly

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Clinical trials

[1]

British Columbia residents >= 65 years of age

1st oral antipsychotic treatment 1996-2004

Study outcome death from any cause

Results:

[2]

Veterans Affairs retrospective study of 10,615 veterans who began psychiatric medication following a dementia diagnosis.

One-year mortality

* antidepressants & anxiolytics/hypnotics

More general terms

References

  1. Schneeweiss S et al, Risk of death with use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ 2007, 176:627 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17325327
  2. Kales HC, Valenstein M, Kim HM, McCarthy JF, Ganoczy D, Cunningham F, Blow FC. Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications. Am J Psychiatry. 2007 Oct;164(10):1568-76. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17898349
  3. Meltzer HY Update on typical and atypical antipsychotic drugs. Annu Rev Med. 2013;64:393-406. Epub 2012 Sep 27. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23020880