bronchial thermoplasty
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Indications
- severe asthma
Clinical significance
- improves asthma control that persists for at least a 10 years in patients with moderate or severe asthma[4]
- for patients with initial asthma exacerbation rates of 50%/year, asthma exacertation rates are 24% at year 1, 22% at year 2, & 25% at year 10 with bronchial thermoplasty vs 37% at year 10 for sham control[4]
Procedure
- radiofrequency ablation of proximal airway smooth muscle
- a series of 3 procedures[2]
Complications
- hospitalizations more common (6%) during the initial 6 week treatment period[2]
- 7% 10 year incidence of new bronchiectasis (clinically insignficant) vs none in sham control[4]
More general terms
Additional terms
References
- ↑ Cox G et al Asthma Control during the Year after Bronchial Thermoplasty N Engl J Med 2007, 356:1327-1337 http://content.nejm.org/cgi/content/short/356/13/1327
- ↑ 2.0 2.1 2.2 Wechsler ME et al. Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol 2013 Aug 30 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23998657
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018
- ↑ 4.0 4.1 4.2 4.3 Chaudhuri R et al. Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): A follow-up of three randomised controlled trials. Lancet Respir Med 2021 May; 9:457. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33524320 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30408-2/fulltext