salivary gland pleiomorphic adenoma

Epidemiology

• most common tumor of the salivary gland
• usually diagnosed in children

Pathology

• benign epithelial tumor
• results from transformation of adipocytes

Genetics

• chromosomal translocation t(3;8)(p21;q12) involving PLAG1 with constitutively expressed beta-catenin/CTNNB1
• chromosomal translocation t(3;8)(p21;q12) involving PLAG1 with TCEA1
• chromosomal translocation t(5;8)(p13;q12) involving PLAG1 with LIFR
• ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleiomorphic adenomas with 8q aberrations
• chromosomal translocation t(7;8)(p22;q13) involving COL1A2 with PLAG1 may be a cause of lipoblastoma

More general terms

• adenoma

Database

• OMIM: https://mirror.omim.org/entry/181030
• OMIM: https://mirror.omim.org/entry/603026