lipoblastoma

Epidemiology

• usually diagnosed in children

Pathology

• benign tumors resulting from transformation of adipocytes

Genetics

• 8q12.1 to 8q24.1 intrachromosomal rearrangement involving PLAG1 with hyaluronic acid synthase 2/HAS2 results in promoter swapping & activation of PLAG1 expression
• the breakpoint of HAS2 gene is in PLAG1 intron 1, whereas its coding sequence starts at exon 2 or exon 3
• chromosomal translocation t(7;8)(p22;q13

More general terms

• lipoma; adipocyte neoplasm