hyaluronan synthase 2; hyaluronate synthase 2; hyaluronic acid synthase 2; HA synthase 2 (HAS2)

Function

• role in hyaluronan/hyaluronic acid synthesis
• glycan biosynthesis; hyaluronan biosynthesis

Cofactor: Mg+2

Structure

belongs to the nodC/HAS family

Compartment

membrane (probable)

Expression

expressed in fibroblasts

Pathology

• chromosomal aberration involving HAS2 with PLAG1 (q12.1 to 8q24.1 intrachromosomal rearrangement) may be a cause of lipoblastomas

More general terms

• hyaluronan synthase (hyaluronic acid synthase, HA synthase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3037
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3037
• OMIM: https://mirror.omim.org/entry/601636
• UniProt: http://www.uniprot.org/uniprot/Q92819.html