hyaluronan synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HA synthase 1; HuHAS1 (HAS1, HAS)

Function

• role in hyaluronan/hyaluronic acid synthesis
• also able to catalyze synthesis of chito-oligosaccharide depending on the substrate
• glycan biosynthesis; hyaluronan biosynthesis

Cofactor: Mg+2

Structure

• belongs to the nodC/HAS family

Compartment

• membrane (probable)

Expression

• expressed in ovary > spleen, thymus, prostate, testes & large intestine > small intestine

More general terms

• hyaluronan synthase (hyaluronic acid synthase, HA synthase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3036
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3036
• OMIM: https://mirror.omim.org/entry/601463
• UniProt: http://www.uniprot.org/uniprot/Q92839.html