aminophylline (ethylene diamine/theophylline, Somophyllin-DF)

Introduction

A 1:1 complex of ethylenediamine & theophylline.

Tradenames: Somophyllin, Somophyllin-DF.

Contraindications

• pregnancy-category C
• safety in lactation ?

Dosage

• Intravenous:
  • Load 6 mg/kg IV over 20-30 minutes.
  • Drip 1 g in 250 mL D5W (4 mg/mL) at 0.5-0.7 mg/kg/hr (70 kg: 0.7 mg/kg/hr = 11 mL/hr).
  • Pediatrics: 1 mg/kg/hr.
• Oral: 200 mg PO TID/QID.

Tabs: 100 & 200 mg.

Liquid: 125 mg/5 mL.

Pharmacokinetics

• elimination: liver

Adverse effects

(also see theophylline)

• uncommon at serum concentrations < 20 ug/mL
• not common (1-10%)
  • nausea/vomiting, restlessness, tachycardia
• uncommon (< 1%)
  • skin rash, insomnia, irritability, tremor, seizures, gastric irritation, allergic reactions

Drug interactions

(see theophylline)

• drug interaction(s) of theophylline with fluvoxamine
• drug interaction(s) of theophylline with macrolide
• drug interaction(s) of theophylline with fluoroquinolone
• drug interaction(s) of lithium carbonate with xanthine

More general terms

• methylxanthine
• antiasthmatic agent
• pharmacologic combination

Components

• ethylenediamine
• theophylline (Slo-Phyllin, Elixophyllin, Uniphyl, Theo-24, Theo-Dur, Slo-bid, Theolair)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9433