olezarsen (Tryngolza)

Indications

• treatment of familial chylomicronemia syndrome

Dosage

• 80 mg SC monthly (0.8 mL 100 mg/mL autoinjector)

Adverse effects

• injection site reactions (pain, redness, swelling)
• upper respiratory tract infections
• headache
• back pain
• allergic reactions
• hepatitis, pancreatitis

• drug adverse effects of anti-hyperlipidemic agents

Mechanism of action

• inhibits production of apolipoprotein C-III (ApoC-III), a protein that slows catabolism of triglycrides

More general terms

• anti-hyperlipidemic agent